Author: bibi
Amantadine Withdrawal
Tuesday, May 20th, 2008 @ 6:24 am
Amantadine (1-aminoadamantane, sold as Symmetrel) is an antiviral drug used both as an antiviral and an antiparkinsonic. Amantadine has been associated with several central nervous system side effects, including nervousness, anxiety, agitation, insomnia, difficulty in concentrating, and exacerbations of pre-existing seizure disorders and psychiatric symptoms in patients with schizophrenia or Parkinson’s disease. These side effects are likely due to amantadine’s dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic. Discontinuing the use of a drug for 3 days or longer may lead to paroxetine and etizolam withdrawal. Although there have been reports of acute delirium1 or neuroleptic malignant syndrome2 after withdrawal of amantadine, discontinuation of amantadine does not commonly induce withdrawal symptoms. Discontinuation of zopiclone is known to cause insomnia. Since the operation was to be conducted under global anesthesia through the inhalation of sevoflurane, oral medication of all drugs was cancelled for the day of operation. When psychotropic therapy was readministered, the psychiatrist decided to remove amantadine from the regimen given its risk of delirium. The day after the operation, the patient showed signs of finger tremors in both hands; however, tremors disappeared by the second day.
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